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目的 :评价阿是止泻胶囊止泻的有效性和安全性。方法 :治疗组用自拟方阿是止泻胶囊 ,对照组用复方苯乙呱啶片。观察其对番泻叶所致小鼠腹泻的作用、对新斯的明所致小鼠小肠运动亢进的影响及急性毒性实验研究。结果 :阿是止泻胶囊可使小鼠湿粪数明显减少 ,使炭末在肠管的推进率降低 ,未测定出小鼠 1次灌胃给药L D50 ,其最大给药量 >2 0 g/ kg。结论 :该药有较强的止泻作用 ,临床应用安全可靠。
Objective: To evaluate the effectiveness and safety of Azai Zhigan Capsules for diarrhea. Methods: The self-made Fanga Shizhi Capsule was used in the treatment group and the compound phenelidine tablets were used in the control group. Observed its role in senna-induced mouse diarrhea, neostigmine-induced mouse intestinal hyperactivity and acute toxicity experimental study. Results: Azaizhixie capsule can significantly reduce the number of wet feces in mice, and reduce the rate of advancement of charcoal in the intestine. The mice were not measured for intragastric administration of L D50. The maximum dose was >2 g. / kg. Conclusion: The drug has a strong antidiarrheal effect, clinical application is safe and reliable.