目的:观察中药分期疗法治疗对复发性流产(RSA)患者子宫血流动力学的影响及预防复发的价值。方法:回顾性分析88例行中药分期治疗联合或单独使用常规西药治疗的肾虚血瘀证RSA患者临床资料,根据其治疗方案分为分期组(n=34)和西药组(n=54)。观察对比其治疗前后BBT上升后第6天子宫血流动力学指标[搏动指数(PI)、阻力指数(RI)]、Th1型、Th2型细胞因子[白细胞介素~2(IL-2)、白细胞介素~4(IL-4)、白细胞介素~6(IL-6)]变化情况,记录其治疗后1年内妊娠及复发情况差异。结果:治疗后,两组PI、RI子宫血流动力学指标及IL-2检测结果均较治疗前显著降低(P<0.05);除RI水平两组对比无统计学意义(P>0.05)外,分期组PI[(2.0±0.4)vs(2.4±0.3)]、L-2[(7.5±1.6)pg/m L vs(9.9±1.5)pg/m L]水平均显著低于西药组(P<0.05)。两组IL-4、IL-6水平则较治疗前显著提升,且分期组>西药组[(2.4±0.8)pg/m L、(2.2±0.5)pg/m L vs(2.0±0.6)pg/m L、(1.6±0.5)pg/m L],差异均具有统计学意义(P<0.05)。治疗后,分期组孕56天胚胎存活率、孕12周胚胎存活率及成功分娩率均显著高于西药组,再次自然流产率则显著低于西药组,差异具有统计学意义(P<0.05)。结论:中药分期疗法能有效改善RSA患者子宫血流动力学状态,对调节其免疫功能、降低复发风险等具有积极影响。 Objective: To observe the effects of traditional Chinese medicine staging therapy on uterine hemodynamics and the value of preventing recurrence in patients with recurrent spontaneous abortion (RSA). Methods: The clinical data of 88 patients with RSA of kidney deficiency and blood stasis treated with traditional Chinese medicine staged by Chinese staging were retrospectively analyzed. They were divided into two groups according to the treatment plan: staging group (n = 34) and western medicine group (n = 54). The levels of uterine hemodynamics [PI (pulsatility index), resistance index (RI)], Th1 type and Th2 type cytokines [interleukin 2 (IL2) Interleukin-4 (IL-4), Interleukin-6 (IL-6)] were recorded. The differences of pregnancy and recurrence within 1 year after treatment were recorded. Results: After treatment, the indexes of uterine hemodynamics and IL-2 in both groups were significantly lower than those before treatment (P <0.05). There was no significant difference between the two groups except RI (P> 0.05) (P <0.05), and the levels of PI [(2.0 ± 0.4) vs (2.4 ± 0.3)] and L-2 [(7.5 ± 1.6) pg / m L vs (9.9 ± 1.5) pg / m L] P <0.05). The levels of IL-4 and IL-6 in the two groups were significantly increased compared with that before treatment, and the levels of IL-4 and IL-6 in the two groups were significantly higher than those in the western medicine group [(2.4 ± 0.8) pg / m L and (2.2 ± 0.5) pg / m L vs / m L, (1.6 ± 0.5) pg / m L], the differences were statistically significant (P <0.05). After treatment, the embryo survival rate at 56 days, the embryo survival rate at 12 weeks and the successful delivery rate in staging group were significantly higher than those in western medicine group, and the spontaneous abortion rate was significantly lower than western medicine group (P <0.05) . Conclusion: The traditional Chinese medicine staging therapy can effectively improve the uterine hemodynamics in RSA patients, which has a positive effect on the regulation of immune function and the risk of relapse.