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血管生成素(Ang)是近年来发现的惟一含有受体激动剂和受体抑制剂的血管生长因子家族。作用于内皮特异受体酪氨酸激酶酪氨酸激酶受体2。Ang及其受体在肿瘤组织中的表达明显高于周围正常组织,且特异表达于肿瘤边缘的血管重建区,参与肿瘤新生血管的形成、延续,影响肿瘤的生长、转移,有望成为一种新的抗肿瘤血管新生的靶向分子。
Angiogenin (Ang) is the only vascular growth factor family found to contain receptor agonists and receptor inhibitors in recent years. Acting on the endothelium-specific receptor tyrosine kinase tyrosine kinase receptor 2. The expression of Ang and its receptor in the tumor tissue was significantly higher than that in the surrounding normal tissue and was specifically expressed in the revascularization zone at the edge of the tumor. It is involved in the formation and continuation of the tumor angiogenesis and affects the growth and metastasis of the tumor. It is expected to become a new Of anti-tumor angiogenesis targeting molecules.