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作者测定了32例慢性胰腺炎病人在注射胰泌素后血清胰多肽的反应。32例在试验前先根据 ERCP 结果分成重度(10例),中度(9例)和轻度(13例)3组。20例正常人作对照组。给病人快速静脉注入2U/kg 的胰泌素,在注射前30、15min 和注射后(?)刻、5、10、15、20、30、45及60min 各取血1次,用放射免疫法(RIA)测定胰多肽水平。各组的基础胰多肽是相同的,注射胰泌素后血清胰多肽都上升,大多数人于注射后5 min 出现高峰值,最迟者不到15min。重度和中度慢性胰腺炎组胰多肽平均高峰值显著低于对照组,而轻度慢性胰腺炎组平均高峰值与对照组相同。因为胰多肽水平是随年龄面上升的,故用基础或刺激后的绝对值评价慢性胰
The authors measured the serum pancreatic polypeptide response in 32 patients with chronic pancreatitis after injection of secretin. Thirty-two patients were divided into three groups: severe (n = 10), moderate (n = 9) and mild (n = 13) according to the results of ERCP. 20 normal subjects as control group. The patients were given intravenous 2 U / kg of secretin. Blood samples were collected at 15, 15, 15 and 30 minutes after injection and once at 5, 10, 15, 20, 30, 45 and 60 minutes respectively. (RIA) to measure pancreatic polypeptide levels. The basal pancreatic polypeptide was the same in all groups. Serum pancreatic polypeptide increased after injection of secretin, and most of the patients showed a peak at 5 min after injection, with the latest being less than 15 min. The average peak value of pancreatic polypeptide in severe and moderate chronic pancreatitis group was significantly lower than that in control group, while the average peak value in mild chronic pancreatitis group was the same as that in control group. Because pancreatic polypeptide levels rise with age, the absolute value of basal or stimulated assessment of chronic pancreatic