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外伤性高颅压症的治疗除广泛应用人工过度换气、类固醇和脑室引流作为辅助治疗外,主要仍依赖高渗脱水剂。甘露醇是目前最常用的高渗剂,但长期应用可引起严重的血浆高渗状态、全身脱水和颅内压(ICP)反跳现象。作者通过12名重度脑损伤患者和3名脑内出血患者,平均年龄为21.3岁,在持续颅内压监护下,对口服甘油的降颅压效果进行了观察。当ICP持续>300
In addition to the treatment of traumatic high intracranial hypertension, extensive use of artificial hyperventilation, steroids and intraventricular drainage as an adjuvant therapy, the main still rely on hypertonic dehydration agent. Mannitol is currently the most commonly used hypertonic agent, but long-term use can cause severe plasma hypertonic conditions, systemic dehydration and intracranial pressure (ICP) rebound phenomenon. By 12 patients with severe brain injury and 3 patients with intracerebral hemorrhage, the mean age was 21.3 years old. Under continuous monitoring of intracranial pressure, the effect of reducing intracranial pressure on oral glycerol was observed. When ICP last> 300