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为探讨幽门螺杆菌(HP)相关性胃炎及十二指肠溃疡与高胃泌素血症的关系。以及根治治疗对血清胃泌素的影响,我们对25例十二指肠球部溃疡和24例慢性胃炎患儿进行空腹血清胃泌素及HP检测,并对15例HP阳性十二指肠球部溃疡患儿应用三联疗法。停药1月后再检测HP与血清胃泌素。结果显示:HP阳性的十二指肠球部溃疡和慢性胃炎患儿血清胃泌素水平高于HP阴性的患儿(t值分别为2.976,3.487,P均<0.01);也高于正常对照组(t值分别为2.686、2.632,P均<0.05)。HP根治后病人血清胃泌素水平较治疗前显著下降(P<0.05)。结论:血清胃泌素水平在HP相关性上消化道疾病中具有重要意义。
To investigate the relationship between Helicobacter pylori (HP) -related gastritis and duodenal ulcer and hypergastrinemia. And radical treatment of serum gastrin impact, we 25 cases of duodenal ulcer and 24 cases of chronic gastritis in children with fasting serum gastrin and HP detection, and 15 cases of HP-positive duodenal bulb Triple ulcers in children with triple therapy. After stopping drug detection of HP and serum gastrin in January. The results showed that: HP-positive duodenal ulcer and chronic gastritis in children with serum gastrin levels higher than the HP-negative children (t values were 2.976,3.487, P <0.01, respectively); also higher than the normal control Group (t values were 2.686,2.632, P <0.05). The level of serum gastrin in patients after radical hp was significantly lower than that before treatment (P <0.05). Conclusion: Serum gastrin levels are important in HP-related upper gastrointestinal diseases.