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单链抗体(single-chain antibodyfragment,scFv)由抗体重链可变区和轻链可变区通过15～20个氨基酸的短肽(linker)连接而成。在目标特定的scFv上连接放射性核素、生物毒素、药物,将极大增强对靶细胞的杀伤能力。Kanter等[1研究发
Single-chain antibody (scFv) is composed of antibody heavy chain variable region and light chain variable region linked by a 15 to 20 amino acid short linker. The attachment of radionuclides, biotoxins and drugs to specific scFv targets will greatly enhance their ability to kill target cells. Kanter et al [1 research and development