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雄性成年SD大鼠灌胃给雷公藤多甙(GTW),每d10mg/kg,每周6次,8周后所有鼠均丧失生育力,再继续用药4周后停药。停药5周后生育力恢复至对照水平。所测各项参数,包括睾九组织学,附睾精子活力和密度,血清睾酮,血清N_a~+、K~+水平,附性腺重量,血象及重要器官的组织学观察均与对照无异。作者认为,所用剂量GTW引起的不育是完全可逆的,而且不遗留任何明显不良机体改变。
Male adult Sprague-Dawley rats were fed with tripterygium wilfordii glycosides (GTW) orally at a dose of 10 mg / kg d 6 times a week for eight weeks. All rats were fertilized and resumed fertilization for 4 weeks. Fertility was restored to control level after 5 weeks of withdrawal. The measured parameters, including testicular histology, epididymal sperm motility and density, serum testosterone, serum N_a ~ +, K ~ + levels, with gonadal weight, blood and vital organs of the histological observations are no different from the control. The authors concluded that sterility caused by the dose GTW was completely reversible without any significant adverse organotypic changes.