我们曾观察到附子具有明显提高小白鼠耐缺氧的能力,对大白鼠急性心肌缺血和心律失常亦有明显的保护和对抗作用。本文进一步验证了附子注射液对麻醉犬急性心肌缺血、左室功能和血液动力学的影响。实验材料与方法实验用健康犬10只,体重13.5±2.9公斤,戊巴妥钠比妥静脉麻醉(30mg/kg)、肝素化(4～5mg/kg)。在人工呼吸下左侧第4～5间开胸,剪开心包缝于胸壁成心包床,暴露心脏。于冠状动脉左前降支的中点或最大斜角支的根 We have observed that aconite has a significant improvement in mice hypoxia tolerance, acute myocardial ischemia in rats and arrhythmias also have significant protective and antagonistic effects. This article further confirmed the aconitum injection on acute myocardial ischemia, left ventricular function and hemodynamics. Experimental Materials and Methods Ten healthy dogs were used, weighing 13.5 ± 2.9 kg, pentobarbital sodium intravenous anesthesia (30 mg / kg) and heparin (4 ~ 5 mg / kg). Left in the artificial respiration under the 4th ~ 5 thoracotomy, cut open the pericardial suture in the chest wall into the bed, exposing the heart. At the midpoint of the left anterior descending branch of the coronary artery or the root of the maximal beveled branch