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目的了解生物胶原纤维刘氏烧伤敷料的性能。方法对生物胶原纤维刘氏烧伤敷料进行生物及物理性测定,包括抗拉力试验、水分蒸发试验、黏附试验、细菌过滤、抗菌试验、皮肤毒性及致敏试验和电镜观察。结果生物胶原纤维刘氏烧伤敷料的抗拉力试验平均拉力为(73.54±11.17)N,水分蒸发试验平均水分丢失为30.884.60g·m-2·h-1,黏附试验平均黏附力为(88.16±36.13)g/cm2,经刘氏烧伤敷料过滤含菌液及刘氏烧伤敷料覆盖下含菌培养皿区均无菌生长,皮肤刺激及致敏试验两者均为阴性,电镜扫描观察该敷料为胶原纤维网状三维纳米结构。结论生物胶原纤维刘氏烧伤敷料是一种无细胞胶原纤维三维纳米结构密闭性敷料,能阻止细菌通过并有抗菌抑菌作用,有良好密闭性能和通透性,抗拉力强和黏附力好。无毒无菌胶原敷料,是理想烧伤创面真皮替代覆盖物。
Objective To understand the properties of bio-collagen fiber LIU burn wound dressing. Methods The biomechanical and physical properties of Liu collagen fiber wound dressing were measured, including tensile test, water evaporation test, adhesion test, bacterial filtration test, antimicrobial test, dermal toxicity, sensitization test and electron microscope observation. Results The average tensile force of tensile test of the bio-collagen fiber Liu burn dressing was (73.54 ± 11.17) N, the average water loss of the water evaporation test was 30.884.60g · m-2 · h-1, the average adhesion of the adhesion test was (88.16 ± 36.13) g / cm2. The samples were filtered through Liu burn dressing and the bacteria-containing culture dish covered by Liu burn dressing were all aseptically grown. Both skin irritation and sensitization tests were negative. Electron microscopy observation of the dressing For the three-dimensional collagen network nanostructures. Conclusion The bio-collagen fiber Liu burn dressing is a three-dimensional acellular collagen-free nano-structured dressing, which can prevent bacteria from passing through and has antibacterial and bacteriostatic effects, good airtightness and permeability, good tensile strength and good adhesion . Non-toxic and sterile collagen dressings, ideal for burn wounds Dermal Substrates.