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目的:比较针灸配合药物治疗与单纯药物治疗男性骨质疏松症患者的疗效差异.方法:将55例男性骨质疏松症患者随机分为针药组(观察组25例)和药物组(对照组30例).观察组在口服阿仑磷酸钠的基础上取脾俞、肾俞、命门、神阙等穴,采用针刺和温灸治疗；对照组单纯口服阿仑磷酸钠.两组均连续治疗6个月后观察临床症状积分和骨密度(BMD)的改善情况.结果:两组患者治疗后症状积分均明显降低(均P＜0.0()1),观察组治疗后较对照组下降更明显( P＜0.001)；观察组腰椎和股骨BMD较治疗前明显提高( P＜0.01,P＜0.05),观察组治疗后腰椎BMD较对照组增加明显(P＜0.05)；对照组部分患者出现腹痛、腹泻、恶心、呕吐、消化不良等,观察组不良反应的程度及出现率较对照组明显减轻和降低.结论:针灸配合药物治疗男性骨质疏松症疗效较好、不良反应小,优于单纯口服阿仑磷酸钠.“,”Objective To compare the therapeutic effects of acupuncture combined with drug and simple drug for treatment of male osteoporosis.Methods Fifty-five cases were divided into a comprehensive therapy group (observation group,25 cases) and a medication (control group,30 cases) randomly.The observation group was treated with acupuncture and moxibustion at Píshū (脾俞 BL 20),Shènshū (肾俞 BL 23),Mìngmén (命门 GV 4),Shénquiè (神阙 CV 8) and so on combined with oral administration of Alendronate,while the control group was treated with oral administration of Alendronate simply.The improvement of both Integral of Clinical Symptoms (ICS) and Bone Mineral Density (BMD) of two groups were observed after 6 months treatment.Results The ICS of two groups after treatment both decreased significantly (both P＜0.001),and the decreasing degree in observation group was more significant than that in control group (P＜0.001).The BMD of lumbar vertebrae and femur in observation group increased obviously than that before treatment (P＜0.01,P＜0.05).The increasing degree of BMD of lumbar vertebrae in observation group after treatment was more obvious than that in control group (P＜0.05).There were abdominal pain,diarrhea,nausea,vomiting,dyspepsia and other adverse reaction in control group,while the degree and occurrence rate of those in observation group alleviated and decreased obviously.Conclusion The effect of acupuncture combined with drug for male osteoporosis is good with little adverse reaction.This method is better than taking Alendronate.