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1例41岁女性患者因肾小球肾炎、肾性高血压给予雷公藤多苷(20 mg,3次/d)、泼尼松(20 mg,1次/d)、缬沙坦(80 mg,1次/d)、苯磺酸氨氯地平(5 mg,1次/d)、碳酸钙(750 mg,3次/d)和骨化三醇(0.25μg,1次/d)口服。治疗1个多月后,患者因月经未来潮停用雷公藤多苷和泼尼松,但停药后月经仍未来潮,共闭经5个月。性激素检查:黄体生成激素29 U/L;卵泡刺激素7 U/L;雌二醇1 168 pmol/L;催乳激素0.02 nmol/L;睾酮0.12 nmol/L;孕酮1.5 nmol/L。给予性激素地屈孕酮10 mg,2次/d口服治疗,连用10 d。停用地屈孕酮后第4天月经来潮,持续5 d。此后患者恢复正常月经周期。
One 41-year-old female patient received tripterygium glycosides (20 mg, 3 times daily), prednisone (20 mg once daily) and valsartan (80 mg) due to glomerulonephritis and renal hypertension. , Once / d), amlodipine besylate (5 mg once daily), calcium carbonate (750 mg three times daily) and calcitriol 0.25 μg once daily. After treatment for more than 1 month, the patient stopped using tripterygium glycoside and prednisone for the future tide of menstruation. However, the menstrual flow still did not come after the withdrawal and had amenorrhea for 5 months. Sex hormones: Luteinizing hormone 29 U / L; Follicle stimulating hormone 7 U / L; Estradiol 1 168 pmol / L; Prolactin 0.02 nmol / L; Testosterone 0.12 nmol / L; Progesterone 1.5 nmol / L. To give sex hormones to bend progesterone 10 mg, 2 times / d oral treatment, once every 10 d. After stopping the use of dorsprone, menstrual cramps on the 4th day lasted for 5 days. After that, the patient resumes normal menstrual cycle.