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生药中的緩下剂自古已認識其优越性,直至今日仍广为賞用。其中特別是含有蒽醌衍生物的大黄,其作用比較緩和,無其他瀉剂所有的習慣性、食慾不振、营养障碍、胃障碍等副作用。亦即大黄对小腸运动無何影响,仅作用于大肠,促进其运动。对肠管的营养吸收亦無妨碍,所以适用于治疗慢性便秘。又对肠管無直接刺激作用。蒽甙在硷性反应的腸內,于胆汁存在下,分解成羟甲基蒽醌(Hydrxymethyl-anthraquinone),刺激肠粘膜,而于投药6—12小时后起瀉下作用。但蒽甙时常惹起下腹部不快感,腹部膨滿感等症狀。如配合抑制此作用的药物,可以消除此类不快的副作用。
Slow down agents in crude drugs have recognized their superiority since ancient times and are still widely appreciated today. Among them, rhubarb, which contains anthraquinone derivatives, has a relatively modest effect and is free from all the side effects of other laxatives such as habits, loss of appetite, nutritional disorders, and gastric disorders. That is, rhubarb has no effect on the small intestine movement, only acting on the large intestine to promote its movement. There is no interference with the nutrient absorption of the intestine, so it is suitable for the treatment of chronic constipation. There is no direct stimulatory effect on the intestine. In the intestine of the spastic reaction, in the presence of bile, it decomposes into Hydroxymethyl-anthraquinone, stimulating the intestinal mucosa, and diarrhea occurs 6 to 12 hours after administration. However, phlegm often causes discomfort in the lower abdomen, abdominal bloating and other symptoms. Such drugs that inhibit this effect can eliminate such unpleasant side effects.