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肝细胞癌(Hepatocellularcarcinoma,HCC)即使是在外科根治术后,其复发率亦极高。对高危人群控制这种肿瘤的高发率是化学预防的目标。癌的化学预防,是指用特定的天然或合成的化学制剂去逆转、抑制阻止癌的发生,作为一种癌控制的新方法,可获得显著成效。本文综述了维甲酸类、干扰素、奥替普拉、COX-2抑制剂、硒、姜黄素及叶绿酸在肝细胞癌化学预防中的作用。化学预防是肿瘤学中出现的一个新领域,人类将会从中受益匪浅。
Hepatocellular carcinoma (HCC) has a very high recurrence rate even after radical surgery. Control of high-risk populations of this high incidence of cancer is the goal of chemical prevention. Chemoprevention of cancer refers to the reversal of the use of specific natural or synthetic chemistries to prevent the onset of cancer. As a novel method of cancer control, significant results are achieved. This article reviews the role of retinoids, interferons, oltipraz, COX-2 inhibitors, selenium, curcumin and chlorophyllin in the chemoprevention of hepatocellular carcinoma. Chemical prevention is a new field in oncology, and mankind will benefit greatly from it.