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目的:通过观察卵巢上皮性癌患者术前、术后及化疗后CA125水平变化,探讨其水平变化对患者预后的评价价值。方法:选取2012年3月至2013年2月间医院诊治的卵巢上皮性癌患者85例为研究对象,所有患者均接受规范的卵巢癌分期手术或卵巢癌细胞减灭术,术后常规进行系统化疗。比较手术及化疗后患者血清CA125水平的变化,分析患者血清CA125水平动态变化、转阴时间与患者预后关系。结果:治疗后,患者CA125水平呈明显下降趋势,差异具有统计学意义(P<0.05)。T1/2≤20 d患者存活时间明显长于T1/2>20 d的患者,差异具有统计学意义(P<0.05)。CA125转阴时间≤8周的患者存活时间长于CA125转阴时间>8周的患者,差异具有统计学意义(P<0.05)。其复发率明显低于CA125转阴时间>8周的患者,复发时间长于CA125转阴时间>8周的患者,差异具有统计学意义(P<0.05)。结论:通过检测血清CA125水平变化可以对卵巢上皮性癌患者预后进行较为准确的评价。
Objective: To observe the changes of CA125 levels in preoperative, postoperative and postoperative chemotherapy of epithelial ovarian cancer patients and to evaluate the prognostic value of the changes in patients with ovarian cancer. Methods: Totally 85 patients with epithelial ovarian cancer diagnosed and treated in our hospital from March 2012 to February 2013 were enrolled in this study. All patients underwent standard ovarian cancer staging or ovarian cancer cytoreductive surgery. The patients were followed up routinely Chemotherapy. The changes of serum CA125 levels in patients after surgery and chemotherapy were analyzed. The dynamic changes of serum CA125 levels were analyzed. The relationship between the negative CAO and the prognosis of patients was analyzed. Results: After treatment, the level of CA125 in patients showed a significant downward trend, the difference was statistically significant (P <0.05). T1 / 2 ≤ 20 d patients survival time was significantly longer than T1 / 2> 20 d patients, the difference was statistically significant (P <0.05). The survival time of patients with CA125 less than 8 weeks was longer than that of patients with CA125 negative> 8 weeks (P <0.05). The recurrence rate was significantly lower than that of patients with CA125 negative> 8 weeks, and the recurrence time was longer than that of CA125> 8 weeks (P <0.05). Conclusion: The prognosis of patients with epithelial ovarian cancer can be evaluated more accurately by detecting the change of serum CA125 level.