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用ＢＡＬＢ／ｃ裸小鼠（ｎｕｄｅｍｉｃｅ，ＮＭ）复制鼻咽癌（ｎａｓｏｐｈａｒｙｎｇｅａｌｃａｒｃｉｎｏｍａ，ＮＰＣ）模型，检测不同病期荷人ＮＰＣＮＭ全血谷胱甘肽过氧化物酶（ｇｌｕｔａｔｈｉｏｎｅｐｅｒｏｘｉｄａｓｅ，ＧＳＨ－ＰＸ）和过氧化氢酶（ｃａｔａｌａｓｅ，ＣＡＴ）活性，结果发现早期荷瘤鼠全血ＧＳＨ－ＰＸ活性明显高于正常裸鼠（Ｐ＜０．０１），然后随着病情发展有所下降，但中或晚期荷瘤鼠全血ＧＳＨ－ＰＸ活性仍高于正常水平（Ｐ＜０．０１）．而荷瘤鼠在潜伏、早和中期全血ＣＡＴ活性与正常裸鼠比较未见明显差异（Ｐ＞０．０５），仅在晚期荷瘤鼠全血ＣＡＴ活性明显低于正常裸鼠（Ｐ＜０．０１）．结果提示ＧＳＨ－ＰＸ和ＣＡＴ活性的改变与ＮＰＣ的发生和发展有关。
Nasopharyngeal carcinoma (NPC) models were replicated with BALB / c nude mice (NM) to detect glutathioneperoxidase (GSH-PX) and peroxidation The activity of GSH-PX in whole blood of early-bearing mice was significantly higher than that of normal nude mice (P <0.01), and then decreased with the progression of the disease. However, GSH-PX activity in rat whole blood was still higher than normal (P <0.01). However, there was no significant difference in latent, early and mid-stage whole blood CAT activity in tumor-bearing mice compared with normal nude mice (P> 0.05). The CAT activity in whole blood of tumor-bearing mice was significantly lower than that in normal nude mice (P < 0.01). The results suggest that the changes of GSH-PX and CAT activity are related to the occurrence and development of NPC.