凝血因子 { Factor ,F ) L eiden突变是引起遗传性静脉血栓病的病因之一。近年的研究表明 F L eiden突变的发生率在不同种族人群中存在明显差异 ,引起了各国学者的广泛关注和兴趣。本文就 F L eiden突变的世界群体分布、起源、形成现行分布及面临选择压力仍能维持较高等位基因频率的可能原因作一综述 Factor {F, F) Leiden mutation is one of the causes of hereditary venous thrombosis. Recent studies have shown that the incidence of F Liden mutation in different ethnic groups there are significant differences have aroused widespread concern and interest of scholars from all countries. In this paper, we review the global population distribution, origin, current distribution of F Leiden mutations and the possible reasons for the high allele frequency of selection pressure