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目的 探讨降钙素基因相关肽（ＣＧＲＰ）与偏头痛发病机理的关系。方法 应用放免法对偏头痛发作期患者肘静脉血、颈外静脉血及脑脊液（ＣＳＦ）中ＣＧＲＰ含量进行测定，并与脑血管病人及正常人作对比。结果 偏头痛患者肘静脉血、颈外静脉血及ＣＳＦ中ＣＧＲＰ含量均明显高于脑血管病人及正常人组（Ｐ＜ ０．０１）。偏头痛发作期颈外静脉血中ＣＧＲＰ含量显著高于肘静脉血中ＣＧＲＰ含量（Ｐ＜ ０．０１）。结论 偏头痛发作与血管活性物质－ ＣＧＲＰ含量变化密切相关。
Objective To investigate the relationship between calcitonin gene-related peptide (CGRP) and the pathogenesis of migraine. Methods Radioimmunoassay (RIA) was used to determine the level of CGRP in elbow venous blood, external jugular vein and cerebrospinal fluid (CSF) in migraine attacks and compared with cerebrovascular patients and normal subjects. Results The levels of CGRP in elbow venous blood, external jugular vein and CSF of migraine patients were significantly higher than those of patients with cerebrovascular disease and normal controls (P <0.01). The content of CGRP in the external jugular vein during migraine attack was significantly higher than that in the elbow vein (P <0.01). Conclusion The onset of migraine is closely related to the change of content of vascular active substance CGRP.