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目的观察PTEN在食管鳞癌组织当中的表达,探讨其与食管鳞癌发生的联系及其临床意义。方法应用免疫组化S-P法检测食管鳞癌组织、癌旁正常食管组织中PTEN的蛋白表达情况。结果 PTEN在正常食管黏膜和食管癌中阳性率分别为96.4%,65.5%。PTEN表达与食管癌的分化程度高低、浸润深度、是否有淋巴结转移和临床分期关系密切(P<0.05),与患者年龄、性别无关(P>0.05)。结论 PTEN蛋白异常表达在食管鳞癌发生发展过程中有重要作用。
Objective To investigate the expression of PTEN in esophageal squamous cell carcinoma (ESCC) and to explore its relationship with esophageal squamous cell carcinoma (ESCC) and its clinical significance. Methods Immunohistochemical S-P method was used to detect the protein expression of PTEN in esophageal squamous cell carcinoma tissues and adjacent normal esophageal tissues. Results The positive rates of PTEN in normal esophageal mucosa and esophageal cancer were 96.4% and 65.5% respectively. There was no correlation between the expression of PTEN and the degree of differentiation, depth of invasion, lymph node metastasis and clinical stage in esophageal cancer (P <0.05), but not with the age and sex of the patients (P> 0.05). Conclusion The abnormal expression of PTEN protein plays an important role in the carcinogenesis and progression of esophageal squamous cell carcinoma.