1例57岁男性胰腺癌患者术后行吉西他滨(1.6g静脉滴注,第1、8天)联合替吉奥胶囊(每粒胶囊含替加氟20 mg、吉美嘧啶5.8 mg及奥替拉西钾19.6 mg,3粒/次,2次/d口服,第1～14天)化疗,21 d为1个周期.用药第3天,患者出现全身烧灼样疼痛,体温最高达39.6℃,四肢及胸背部散发紫红色斑疹.立即停用替吉奥胶囊,吉西他滨继续应用.用药第5天,患者四肢内侧及胸背部出现大面积多型性皮疹,部分皮疹中心出现水泡,部分皮疹呈红色大疱并融合成片,部分大疱破溃、暴露创面；同时伴有口腔黏膜糜烂.给予对症处理,2周后患者皮疹基本消失.1周后行吉西他滨联合氟尿嘧啶化疗2个周期,卡培他滨化疗2个周期,未再出现皮疹.“,”A 57-year-old male patient with pancreatic cancer received postoperative chemotherapy with an Ⅳ infusion of gemcitabine 1.6 g on days 1 and 8 combined with 3 capsules of tegafur,gimeracil and oteracil potassium orally (each capsule contains tegafur 20 mg,gimeracil 5.8 mg,and oteracil potassium 19.6 mg) twice daily on days 1-14 and one cycle took 21 days.On day 3 of drug use,the patient developed generalized burning pain and his highest temperature reached 39.6 ℃.Sporadic prunosus pruritus appeared in his limbs,chest,and back.Tegafur,gimeracil and oteracil potassium capsules were stopped immediately and gemcitabine was continued.On day 5 of drug use,the inside of his limbs,chest,and back were covered a large area of erythema multiforme,of which experienced vesicular in the center,red bulla fusing into lamella,and rupture and wound exposure,accompanied by erosive oral mucosa at the same time.Symptomatic treatments were given and,two weeks later,the rashes basically subsided.One week later,he received two cycles of combination chemotherapy with gemcitabine and fluorouracil and two cycles of capecitabine for chemotherapy as well and the rashes did not recur.