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目的观察云克和89Sr联合治疗乳腺癌骨转移患者癌性疼痛的效果。方法对22例确认为骨转移癌患者89Sr治疗,每次剂量3~4mCi静脉给药,间隔3个月;5d后注射89Sr静脉滴注云克22mg/d,连续10d,每月一疗程,连用3~6个月。结果本次治疗乳腺癌骨转移患者22例,疼痛完全缓解8例,部分缓解10例,轻度缓解2例,无效2例,总有效率90.90%。骨病灶的消除:全组病例骨病灶完全缓解6例,部分缓解12例,4例稳定或无效,有效率为81.82%。结论云克和89Sr联合治疗乳腺癌骨转移引起的癌性疼痛,取得了很好的止痛效果,对转移癌引起的骨质破坏有明显的修复作用,从而在一定程度上提高晚期乳腺癌骨转移患者的生活质量。
Objective To observe the effect of combination of Yunke and 89Sr on cancerous pain in patients with bone metastasis of breast cancer. Methods Twenty-two patients with bone metastases were treated with 89Sr for 3 ~ 4 mCi every 3 months. After 5 days, 89Sr intravenous drip of 22 mg / d was given for 10 days, once a month for treatment. 3 to 6 months. Results The treatment of breast cancer patients with bone metastases in 22 cases, complete pain relief in 8 cases, partial remission in 10 cases, mild remission in 2 cases, 2 cases, the total effective rate was 90.90%. Elimination of bone lesions: bone lesions in all patients complete remission in 6 cases, partial remission in 12 cases, 4 cases were stable or ineffective, the effective rate was 81.82%. Conclusions Yunke and 89Sr combined treatment of cancer pain caused by bone metastasis of breast cancer, and achieved good analgesic effect on the bone metastasis caused by metastases significantly repair the role, which to some extent, to improve bone metastasis of advanced breast cancer Quality of life of patients.