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目的调查上海地区健康人群血清胱抑素C水平,建立上海地区的血清胱抑素C正常参考范围。方法收集2014年5月至2016年5月体检健康者血清胱抑素C的检测结果,按性别、年龄、采集时间(季度)分组,采用颗粒增强免疫透射比浊法测定血清胱抑素C,分析胱抑素C与性别、年龄、季度的相关性。结果健康人群的血清胱抑素C水平与性别、年龄有关,与季度无关。随年龄增长,血清胱抑素C水平呈现上升趋势。以95%可信度制定上海地区健康人群血清胱抑素C水平的参考范围为:<40岁:男性0.62~1.14 mg/L,女性0.51~1.02 mg/L;40~59岁:男性0.54~1.23mg/L,女性0.55~1.20mg/L;≥60岁男性0.73~1.55mg/L,女性0.70~1.50mg/L。结论上海地区健康人群的血清胱抑素C水平存在性别、年龄差异,应建立不同的正常参考范围。
Objective To investigate the level of serum cystatin C in Shanghai healthy people and establish the normal reference range of serum cystatin C in Shanghai. Methods The data of serum cystatin C from May 2014 to May 2016 were collected and divided into groups according to sex, age and collection time (quarterly), and serum cystatin C was measured by particle-enhanced immunoturbidimetry. Analysis of cystatin C and gender, age, quarterly correlation. Results The level of serum cystatin C in healthy population was related to sex and age, but not to the quarterly rate. With age, serum cystatin C levels showed an upward trend. The reference range for setting serum cystatin C level in Shanghai healthy population at 95% confidence level was: <40 years: male 0.62-1.14 mg / L, female 0.51-1.02 mg / L; 40-59 years old: male 0.54 ~ 1.23mg / L, 0.55 ~ 1.20mg / L for women; 0.73 ~ 1.55mg / L for men aged 60 or older, and 0.70 ~ 1.50mg / L for women. Conclusion Serum levels of cystatin C in Shanghai healthy population have different gender and age, and different normal reference ranges should be established.