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目的:探讨姜黄素(crucumin)治疗大鼠子宫内膜异位症的治疗机制。方法:采用雌性SD清洁级大鼠建立模型子宫内膜异位症模型,分为空白对照组、模型组、孕三烯酮组、姜黄素组。给药3周后,酶联免疫反应法(ELISA)测血清雌二醇(E2)、孕酮(P)的含量,SP法检测异位子宫内膜组织雌激素受体α(ERα)、雌激素受体β(ERβ)、孕激素受体(PR)的表达。结果:孕三烯酮组、姜黄素组血清E2、P含量和异位组织ERα、ERβ、PR的表达与模型组比较差异有统计学意义(P<0.05),孕三烯酮组、姜黄素组组间无明显差异(P>0.05)。结论:姜黄素能降低血清E2、大鼠子宫内膜异位组织ERα、ERβ表达,提高血清P含量与异位组织PR的表达,抑制模型大鼠异位内膜的生长,实现治疗目的。
Objective: To investigate the therapeutic mechanism of crucumin in the treatment of endometriosis in rats. Methods: A model of endometriosis was established in female SD clean rats and divided into blank control group, model group, gestrinone group and curcumin group. Serum estradiol (E2) and progesterone (P) were measured by enzyme-linked immunosorbent assay (ELISA) after 3 weeks of administration. The levels of estrogen receptor alpha (ERα) Hormone receptor β (ERβ), progesterone receptor (PR) expression. Results: The levels of E2 and P and the expressions of ERα, ERβ and PR in the gestagene and curcumin groups were significantly different from those in the model group (P <0.05). The levels of E2 in the gestrinone group and the curcumin group There was no significant difference between groups (P> 0.05). CONCLUSION: Curcumin can decrease the expression of ERα and ERβ in serum E2 and rat endometriosis, increase the content of serum P and the expression of PR in ectopic tissues, and inhibit the growth of ectopic endometrium in the model rats for the purpose of treatment.