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目的探讨临床表型分类系统(UPOINT)在慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)患者中的应用。方法 2012年2月至10月收治241例CP/CPPS患者。采用UPOINT表型分类方法对患者进行分类,同时运用慢性前列腺炎症状指数表(NIH-CPSI)和国际前列腺症状评分(IPSS)评估患者症状。结果 241例患者CPSI总分为20.78±5.89,患者生活质量得分8.94±2.26,IPSS得分8.08±4.85。UPOINT各因子所占比例分别为58.9%、60.2%、86.3%、26.6%、26.1%、39.8%。具有1个因子的患者占9.5%,2个因子占29.9%,3个因子占27%,4个因子占21.6%,5个以上因子占12%。患者所具因子数目与NIH-CPSI、IPSS症状严重程度相关(r1=0.61,r2=0.45;P<0.01),慢性前列腺炎症状指数表中生活质量得分(CPSI QoL)与因子数目呈正相关(r=0.48,P<0.01)。结论 UPOINT临床表型分类方法对CP/CPPS患者临床症状进行分类,不仅提高诊断率,同时为患者提供个性化治疗方案,提高患者生活质量。
Objective To investigate the clinical application of UPOINT in chronic prostatitis / chronic pelvic pain syndrome (CP / CPPS) patients. Methods From February to October 2012, 241 patients with CP / CPPS were admitted. Patients were classified using the UPOINT phenotypic classification and symptoms were assessed using the NIH-CPSI and IPSS. Results The total score of CPSI in 241 patients was 20.78 ± 5.89, the quality of life score was 8.94 ± 2.26 and the score of IPSS was 8.08 ± 4.85. The proportions of UPOINT factors were 58.9%, 60.2%, 86.3%, 26.6%, 26.1% and 39.8% respectively. Patients with 1 factor accounted for 9.5%, 2 factors accounted for 29.9%, 3 factors accounted for 27%, 4 factors accounted for 21.6%, 5 or more factors accounted for 12%. The number of patients with NIH-CPSI, IPSS severity of symptoms (r1 = 0.61, r2 = 0.45; P <0.01), chronic prostatitis symptom index table quality of life score (CPSI QoL) was positively correlated with the number of factors = 0.48, P <0.01). Conclusion UPOINT clinical phenotypic classification of clinical symptoms in patients with CP / CPPS classification, not only improve the diagnostic rate, at the same time provide patients with personalized treatment programs to improve the quality of life of patients.