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目的:探讨鸦胆子注射液联合同步放化疗治疗Ⅲ期非小细胞肺癌的临床疗效和不良反应。方法:90例Ⅲ期非小细胞肺癌患者随机分为两组,对照组45例同步放化疗治疗,观察组45例在放射治疗同时给予鸦胆子油乳注射液,观察和比较两组在临床疗效及不良反应的差异。结果:观察组有效率为57.8%,对照组为37.8%,两组比较差异有统计学意义(P<0.05),两组患者1年生存率、局部复发率及远处转移率、不良反应比较,差异无统计学意义(P>0.05)。结论:在同步放化疗的基础上,加用鸦胆子注射液治疗Ⅲ期非小细胞肺癌,虽然未能改善患者的远期预后,但提高患者的近期临床疗效,未增加不良反应,值得临床推广。
Objective: To investigate the clinical efficacy and adverse reactions of Brucea javanica injection combined with concurrent chemoradiotherapy in the treatment of stage Ⅲ non-small cell lung cancer. Methods: Ninety patients with stage Ⅲ non-small cell lung cancer were randomly divided into two groups. 45 cases in the control group received concurrent chemoradiotherapy. 45 cases in the observation group received Brucea javanica oil injection simultaneously with radiotherapy. The clinical efficacy And differences in adverse reactions. Results: The effective rate was 57.8% in the observation group and 37.8% in the control group, with significant difference between the two groups (P <0.05). The 1-year survival rate, local recurrence rate, distant metastasis rate and adverse reactions in the two groups were compared , The difference was not statistically significant (P> 0.05). Conclusions: On the basis of concurrent chemoradiotherapy, plus Brucea javanica injection in the treatment of stage Ⅲ non-small cell lung cancer, although not improve the long-term prognosis of patients, but to improve the patient’s recent clinical efficacy, no adverse reactions, is worthy of clinical promotion .