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目的探讨直肠癌患者外周血s IL-2R和IL-8水平与直肠癌患者自我效能、生活质量及临床预后的关系。方法选取本院2012年8月-2015年8月行结直肠癌根治术的患者95例,所有患者均经病理确诊为直肠癌,检测患者外周血s IL-2R和IL-8水平,评价患者术后自我效能、生活质量,Pearson相关性分析外周血s IL-2R和IL-8水平与患者临床指标的关系。结果 95例患者死亡4例,以死亡或肿瘤转移、复发为终点事件,出现终点事件的患者19例,终点事件发生率为20%。s IL-2R高水平和IL-8高水平患者生活质量和自我效能均明显低于低水平患者。生活质量评分、自我效能评分与肿瘤直径、N分期、s IL-2、IL-8水平呈负相关。年龄(P=0.02)、肿瘤N分期(P=0.04)、s IL-2R(P=0.03)、IL-8(P=0.02)是直肠癌患者死亡、转移或复发的独立危险因素。结论 s IL-2R和IL-8水平与直肠癌患者自我效能及生存质量评分密切相关,是直肠癌患者死亡的独立危险因素。
Objective To investigate the relationship between the levels of sIL-2R, IL-8 in peripheral blood of patients with rectal cancer and the self-efficacy, quality of life, and clinical prognosis of patients with rectal cancer. Methods Ninety-five patients undergoing radical resection of colorectal cancer from August 2012 to August 2015 in our hospital were selected. All patients were diagnosed as rectal cancer by pathology. The levels of sIL-2R and IL-8 in peripheral blood were measured and evaluated. Postoperative self-efficacy, quality of life, and Pearson correlation analysis were used to analyze the relationship between peripheral blood sIL-2R and IL-8 levels and clinical indicators. Results Of the 95 patients, 4 died. The death or tumor metastasis and recurrence were the end events. There were 19 patients with end-point events, and the end-event rate was 20%. The quality of life and self-efficacy of patients with high levels of IL-2R and high levels of IL-8 were significantly lower than those with low levels. The quality of life and self-efficacy scores were negatively correlated with tumor diameter, N stage, sIL-2, and IL-8 levels. Age (P=0.02), tumor N stage (P=0.04), sIL-2R (P=0.03), and IL-8 (P=0.02) were independent risk factors for death, metastasis or recurrence in patients with rectal cancer. Conclusion The levels of IL-2R and IL-8 are closely related to the self-efficacy and quality of life scores in patients with rectal cancer, and are independent risk factors for the death of patients with rectal cancer.