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目的研究单、双侧卵巢切除对围绝经期女性生活质量的影响。方法选取妇产科进行单、双侧卵巢切除术的围绝经期患者90例,其中单侧45例,双侧45例,比较两组受试者的FSH、LH、E2水平、骨密度变化及其绝经相关症状。结果单侧组后3、6个月FSH、LH升高,E2下降与术前比较差异有统计学意义(P<0.05),双侧组术后3、6、12个月FSH、LH升高,E2下降,与术前比较,差异有统计学意义(P<0.05)。在术后3、6、12个月,两组的骨密度与术前相比,均没有显著变化(P>0.05)。术后3、6、12个月,双侧组患者的绝经相关症状均显著高于单侧组,差异有统计学意义(P<0.05)。结论双侧卵巢切除与单侧卵巢切除术比较,妇女术后体内激素水平急骤改变,对患者的生活质量影响更严重,应该尽可能的保存卵巢的功能。
Objective To study the effect of single or bilateral ovariectomy on the quality of life of perimenopausal women. Methods 90 cases of perimenopausal women with single and bilateral ovariectomy were selected in this study. Among them, 45 cases were unilateral and 45 cases were bilateral. The levels of FSH, LH, E2 and the changes of BMD were compared between the two groups Its menopause related symptoms. Results The levels of FSH, LH and E2 in the unilateral group at 3 and 6 months after operation were significantly different from those before operation (P <0.05). The levels of FSH and LH increased at 3, 6 and 12 months , E2 decreased, compared with preoperative, the difference was statistically significant (P <0.05). At 3, 6, and 12 months after operation, there was no significant difference in BMD between the two groups (P> 0.05). The postmenopausal symptoms in both groups were significantly higher than those in unilateral group at 3, 6 and 12 months after operation (P <0.05). Conclusion Compared with unilateral ovariectomy, bilateral ovariectomy has a sudden change of hormone level in postoperative patients, which has a more serious impact on the quality of life of the patients. The function of ovary should be saved as much as possible.