【摘 要】
：
目的了解血浆内皮素-1(ET-1)在梗阻性黄疸大鼠冷应激状态下的水平及与肾功能损害的关系.方法实验动物随机分为4组:①假手术(SO)组;②胆总管结扎(BDL)组;③胆总管结扎应激(BS)
【机 构】
：
第四军医大学唐都医院普外科,陕西西安710038
论文部分内容阅读
目的了解血浆内皮素-1(ET-1)在梗阻性黄疸大鼠冷应激状态下的水平及与肾功能损害的关系.方法实验动物随机分为4组:①假手术(SO)组;②胆总管结扎(BDL)组;③胆总管结扎应激(BS)组;④BS加ET抗血清(BAS)组.采用放射免疫的方法测定各组动物的血浆ET-1含量.结果 BS组ET-1(206.72ng/ml±34.31ng/ml)明显高于BDL对照组(168.63ng/ml±26.58ng/ml)(P<0.05).血尿素氮(BUN)(12.31mmol/L±3.14mmol/L)和肌酐(Cr)(71.64mmol/L±9.14mmol/L) 也较BDL组升高(P<0.05),BUN和Cr也均下降,ET-1与BUN,Cr均呈正相关(r=0.743,r=0.831).结论梗阻性黄疸大鼠血浆ET-1在应激状态下明显升高,与BUN和Cr呈正相关,致使梗阻性黄疸大鼠的肾功能损害加重.
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