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目的：探讨MIS-TLIF单侧与双侧椎弓根固定治疗腰椎间盘突出症疗效比较情况。方法分析该院2013年6月—2015年6月收治的80例腰椎间盘突出症患者临床资料,依据治疗方式不同进行分组,MIS-TLIF单侧固定组40例和双侧椎弓根固定组40例。结果 MIS-TLIF单侧固定组腰椎间盘突出症患者手术时间、术中出血量均低于双侧椎弓根固定组,P0.05,治疗后两组腰椎间盘突出症患者VAS评分和ODI评分均优于治疗前,P0.05。结论 MIS-TLIF单侧与双侧椎弓根固定治疗腰椎间盘突出症疗效均较好,MIS-TLIF单侧固定创伤较小。“,”Objective To approach comparative efficacy of minimally invasive transforaminal lumbar interbody fusion uni-lateral and bilateral fixed pedicle fixation for the treatment of lumbar disc herniation. Methods The 80 cases clinical data of lumbar disc herniation patients in our hospital from June 2013 to June 2015 were analyzed,which was to be divided into two groups by different treatment methods,minimally invasive transforaminal lumbar interbody fusion unilateral group 40 cases and bilateral fixed pedicle fixation group 40 cases. Results The operation time、lntraoperative blood loss of minimally invasive transforaminal lumbar interbody fusion unilateral group were lower than bilateral fixed pedicle fixation group,P0.05,the VAS score and ODI score of minimally invasive transforaminal lumbar in-terbody fusion unilateral group lumbar disc herniation patients after operation were better than before treatment,P0.05. Conclusion The curative effect of minimally invasive transforaminal lumbar interbody fusion unilateral and bilateral fixed pedicle fixation are good,the injury of minimally invasive transforaminal lumbar inter-body fusion unilateral is little.