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高血压患者有较高心律失常的发生率，房性心律失常可能与左房扩大或心房纤维化有关。为观察压力负荷增高大鼠中心房纤维化的发生情况，将Ｗｉｓｔａｒ大鼠随机分成假手术组和手术组，手术组大鼠行肾上腹主动脉部分结扎。术后４，８，１２周分别测定大鼠颈动脉压及心房胶原容积分数（ＣＶＦ），结果发现：①手术组左室舒张压明显高于假手术组（４，８，１２周分别为１８．５±２．５ｋＰａｖｓ１５．７±１．９ｋＰａ，１８．６±２．７ｋＰａｖｓ１５．３±１．３ｋＰａ，１９．６±３．１ｋＰａｖｓ１５．２±１．９ｋＰａ，Ｐ＜０．０５或０．０１）。②手术组心房ＣＶＦ明显高于假手术组（４，８，１２周左、右房分别比较：４．２３±０．７６％ｖｓ２．９３±０．８７％，４．６５±１．４５％ｖｓ３．１１±１．０７％，５．６２±１．６２％ｖｓ３．２３±１．２８％；３．８８±１．１５％ｖｓ２．５１±０．８４％，４．２４±１．６５％ｖｓ２．５１±０．８４％，５．３４±１．３２％ｖｓ２．３３±１．１４％；Ｐ＜０．０５或０．０１），手术组心房ＣＶＦ有逐渐上升趋势。③左房ＣＶＦ与左室舒张压之间无直线相关关系（ｒ＝０．１６９１，Ｐ＞０．０５）。提示在高血压大鼠模型中存在心房?
Hypertension patients have a higher incidence of arrhythmias, atrial arrhythmia may be related to left atrium enlargement or atrial fibrosis. To observe the occurrence of atrial fibrosis in rats with increased pressure overload, Wistar rats were randomly divided into sham operation group and operation group. The rats in operation group were partially ligated to the abdominal aorta. The carotid artery pressure and atrial collagen volume fraction (CVF) were measured at 4, 8 and 12 weeks after operation. The results showed that: ① The left ventricular diastolic pressure in the operation group was significantly higher than that in the sham operation group (4, 8 and 12 weeks respectively) .5 ± 2.5 kPavs 15.7 ± 1.9 kPa, 18.6 ± 2.7 kPavs 15.3 ± 1.3 kPa, 19.6 ± 3.1 kPavs 15.2 ± 1.9 kPa, P <0.05 or 0.01 ). ② The CVF of the atrial tissue in the operation group was significantly higher than that in the sham operation group (4, 8 and 12 weeks, respectively, compared with 4.23 ± 0.76% vs 2.93 ± 0.87% and 4.65 ± 1.45% vs3.11 ± 1.07%, 5.62 ± 1.62% vs3.23 ± 1.28%; 3.88 ± 1.15% vs2.51 ± 0.84%, 4.24 ± 1.65 % Vs2.51 ± 0.84%, 5.34 ± 1.32% vs2.33 ± 1.14% respectively; P <0.05 or 0.01). The CVF of the atria in the operation group increased gradually. There was no linear relationship between left atrial CVF and left ventricular diastolic pressure (r = 0.1691, P> 0.05). Tip Hypertension rat model in the presence of atrial?