目的探讨二甲双胍治疗社区老年2型糖尿病患者的临床效果和安全性。方法选取社区老年糖尿病患者90例为研究对象,按随机数表法分为对照组和观察组,每组45例。对照组患者采用瑞格列奈治疗,观察组患者采用二甲双胍治疗,比较两组患者的血糖控制情况和不良反应发生情况。结果观察组患者的治疗总有效率为95.6%,显著高于对照组的80.0%,差异有统计学意义(P<0.05);观察组患者的空腹血糖、餐后2 h血糖及糖化血红蛋白水平分别为(6.1±1.0)mmol/L、(7.1±1.7)mmol/L、(9.4±2.0)%,均显著低于对照组的(8.0±1.6)mmol/L、(8.3±1.6)mmol/L、(10.7±2.3),差异有统计学意义(P<0.05);观察组患者的不良反应发生率为6.7%,显著低于对照组的22.2%,差异有统计学意义(P<0.05)。结论二甲双胍治疗社区老年2型糖尿病有利于控制患者的血糖,且能够降低各类不良事件的发生风险,安全性高。 Objective To investigate the clinical effect and safety of metformin in the treatment of elderly type 2 diabetes in community. Methods Ninety elderly patients with diabetes mellitus in the community were selected as study objects, divided into control group and observation group by random number table method, with 45 cases in each group. The patients in the control group were treated with repaglinide. The patients in the observation group were treated with metformin. The control of blood glucose and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of observation group was 95.6%, which was significantly higher than that of control group (80.0%, P <0.05). The fasting blood glucose, postprandial 2-hour postprandial blood glucose and glycosylated hemoglobin Were (6.1 ± 1.0) mmol / L, (7.1 ± 1.7) mmol / L and (9.4 ± 2.0)% respectively, which were significantly lower than those in the control group (8.0 ± 1.6 mmol / L and 8.3 ± 1.6 mmol / L , (10.7 ± 2.3) respectively. The difference was statistically significant (P <0.05). The adverse reaction rate in the observation group was 6.7%, which was significantly lower than that in the control group (22.2%, P <0.05). Conclusion Metformin treatment of community-aged type 2 diabetes mellitus is beneficial to control the blood sugar of patients, and can reduce the risk of various adverse events and is safe.