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半乳糖基修饰的清蛋白可作为肝炎药物的引导蛋白,将药物浓集到肝实质细胞上。我们通过改进的方法制备2-亚氨基-2-甲氧基-乙基1-硫-半乳糖苷,并将此活性半孔糖衍生物连接到清蛋白上。所合成的糖蛋白经气相色谱测定,每分子蛋白上连接44个半乳糖基。
Galactosyl-modified albumin acts as a leader protein for hepatitis drugs and concentrates the drug on hepatic parenchymal cells. We prepared 2-imino-2-methoxy-ethyl 1-thio-galactoside by an improved method and attached this active hemicellulose derivative to albumin. The synthesized glycoproteins were analyzed by gas chromatography and 44 galactosyl groups were bound to the protein per molecule.