自二十世纪初,人们陆续发现由“大分子”包含小分子形成加合物的现象。1916年 Wie-land 等发现络胆酸(Choleic acid)是由去氧胆酸(Desoxycholic acid)和脂肪酸形成的加合物。1940年 Bengen 分离得到了尿素—辛醇加合物的针状结晶,由 Schlenk 和 Smith 等确定了尿素加合物的结构。后来发现,除去氧胆酸和尿素外,还有些化合物,例如氢醌、 Since the early twentieth century, people gradually discovered the phenomenon of adducts formed by small molecules contained in “macromolecules”. In 1916 Wie-land et al. Found that choleic acid is an adduct of desoxycholic acid and fatty acid. In 1940, Bengen separated the needle crystals of urea-octanol adduct and the structure of urea adduct was determined by Schlenk and Smith et al. Later found that in addition to the removal of acid and urea, but also some compounds, such as hydroquinone,