论文部分内容阅读
目的 观察自体外周血干细胞移植 (APBSCT)治疗难治性系统性红斑狼疮 (RSLE)的疗效及安全性。方法 RSLE 3例 ,先给予血浆置换、环磷酰胺 (CTX)和大剂量丙种球蛋白 ,然后用环磷酰胺和粒细胞集落刺激因子 (G CSF)动员造血干细胞 (HSC) ,多功能加强型血细胞分离机采集外周血干细胞 ,-86℃超低温冻存 ,环磷酰胺预处理 ,经静脉回输干细胞 ,最后应用抗胸腺淋巴细胞球蛋白 (ATG)行体内去T淋巴细胞。观察移植前后临床症状、体征和免疫学指标的变化。结果 APBSCT后患者的临床症状完全缓解 ,异常免疫学指标基本恢复正常 ,抗体全部转阴。结论 APBSCT对难治性系统性红斑狼疮有明显的疗效 ,尤其适用对各种药物治疗无效的患者 ,远期疗效还需长期随访
Objective To observe the efficacy and safety of autologous peripheral blood stem cell transplantation (APBSCT) in the treatment of refractory systemic lupus erythematosus (RSLE). Methods Three patients with RSLE were treated with plasma exchange, CTX and high dose gamma globulin, and then mobilized hematopoietic stem cells (HSC) and multifunctional enhanced blood cells with cyclophosphamide and granulocyte colony stimulating factor (G CSF) Separation of peripheral blood stem cells collected, cryopreserved at -86 ℃, cyclophosphamide pretreatment, intravenous transfusion of stem cells, the final application of anti-thymus lymphocyte globulin (ATG) in vivo to T lymphocytes. The changes of clinical symptoms, signs and immunological indexes before and after transplantation were observed. Results The clinical symptoms of patients after APBSCT were completely relieved. The abnormal immunological indexes returned to normal and the antibodies turned negative. Conclusions APBSCT has obvious curative effect on refractory systemic lupus erythematosus, especially for those patients who are ineffective in all kinds of medical treatment, long-term follow-up is still needed