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目的分析湖州市实施现行结核病控制策略对耐药变迁状况的影响。方法收集2001—2004年(第1次监测)和2009年7月—2010年6月(第2次监测)湖州市各县(市、区)结核病新登记痰培养阳性并鉴定为结核分枝杆菌的结核病患者标本192和772份,培养阳性菌株标本做药敏试验,药敏试验采用比例法。结果第1次监测与第2次监测相比,总耐药率由25.25%下降至15.41%,差异有统计学意义(P<0.01);总耐多药率由6.88%下降至3.50%,差异有统计学意义(P<0.01);获得性耐药率自51.30%下降至43.02%,差异无统计学意义(P>0.05);初始耐药率由19.02%下降至11.95%,差异有统计学意义(P<0.01)。结论现行结核病控制策略实施下,结核病耐药率有所下降。
Objective To analyze the effect of the current TB control strategy on the drug resistance in Huzhou City. Methods The newly registered sputum cultures of TB from 2001 to 2004 (the first monitoring) and July 2009 to June 2010 (the second monitoring) in all counties (cities and districts) in Huzhou were collected and identified as Mycobacterium tuberculosis Of 192 and 772 specimens of TB patients, the positive strain specimens were cultured for susceptibility testing, drug sensitivity test using the proportion method. Results Compared with the second surveillance, the first surveillance showed that the overall rate of resistance dropped from 25.25% to 15.41%, with a significant difference (P <0.01). The overall rate of multidrug resistance decreased from 6.88% to 3.50% (P <0.01). The rate of acquired drug resistance decreased from 51.30% to 43.02%, the difference was not statistically significant (P> 0.05). The initial drug resistance rate decreased from 19.02% to 11.95%, the difference was statistically significant Significance (P <0.01). Conclusion Under the current TB control strategy, the rate of TB drug resistance has declined.