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目的总结应用高压氧(HBO)综合治疗小儿急重型缺氧性脑损伤(hypoxic-ischemic brain damage,HIBD)的临床经验。方法回顾分析郑州大学第五附属医院2003-2010年收治的80例因各种原因造成的小儿急重型HIBD的临床资料。结果 HBO治疗组和对照组总有效率分别为95.5%和72.2%,HBO治疗组优于对照组,差异有统计学意义(P<0.05)。结论高压氧通过增加大脑的血氧含量、收缩脑血管减轻脑水肿、增加椎动脉供血等来保护神经细胞,促进患者苏醒,改善患者的神经功能,HBO综合治疗小儿重型HIBD效果显著。
Objective To summarize the clinical experience of using hyperbaric oxygen (HBO) in the treatment of children with hypoxic-ischemic brain damage (HIBD). Methods The clinical data of 80 children with acute severe HIBD caused by various causes admitted to the Fifth Affiliated Hospital of Zhengzhou University from 2003 to 2010 were retrospectively analyzed. Results The total effective rates of HBO treatment group and control group were 95.5% and 72.2%, respectively, HBO treatment group was superior to the control group, the difference was statistically significant (P <0.05). Conclusion Hyperbaric oxygen can protect neurons by increasing cerebral blood oxygen content, contracting cerebrovascular and decreasing cerebral edema, increasing the blood supply of vertebral artery, promoting the recovery of patients and improving the neurological function of patients. HBO treatment has a significant effect on the treatment of severe HIBD in children.