目的：考察４℃、２５℃、３７℃下２４ｈ内替硝唑葡萄糖注射液与注射用头孢噻肟钠的配伍稳定性。方法：采用反相高效液相色谱法测定配伍后４℃、２５℃、３７℃下２４ｈ内不同时间替硝唑与头孢噻肟钠的含量，同时观察外观并测定ｐＨ值。结果：在３种温度下２４ｈ内，配伍液的 ｐＨ值无明显变化；配伍液的外观、替硝唑和头孢噻肟钠的含量随时间有明显变化；在 ４℃ ６ｈ时、２５℃２ｈ时、３７℃１ｈ时，配伍液的吸收曲线发生微小变化，产生了新的最大吸收峰位。结论：在４℃ ６ｈ内、２５℃２ｈ内、３７℃１ｈ内，替硝唑葡萄糖注射液与注射用头孢噻肟钠的配伍液稳定。 OBJECTIVE: To investigate the compatibility of tinidazole and dexamethasone injection with Cefotaxime sodium for 24 hours at 4 ℃, 25 ℃ and 37 ℃. Methods: The contents of tinidazole and cefotaxime sodium in different time of 24h, 25 ℃, 37 ℃ were determined by reversed-phase high-performance liquid chromatography. The appearance and the determination of pH were also observed. Results: There was no significant change in the pH value of the compatibility solution within 24h of the three temperatures. The content of tinidazole and cefotaxime sodium changed significantly with the appearance of the compatibility solution at 6h at 4 ℃ and 2h at 25 ℃ , 37 ℃ 1h, the absorption curve of the minor changes occur, resulting in a new maximum absorption peak. Conclusion: The compatibility of tinidazole glucose injection and cefotaxime sodium for injection is stable within 6h at 4 ℃, within 2h at 25 ℃ and within 1h at 37 ℃.