人诺如病毒是引起婴幼儿非细菌性胃肠炎的主要病原体之一.诺如病毒感染可引起恶心、呕吐、腹泻及腹痛等临床症状,其中呕吐表现较明显.由于缺少有效的研究模型,目前对诺如病毒感染的发病机制尚不清楚.文章重点阐述诺如病毒致病机制的研究进展,并主要集中于细胞噬性及免疫应答.“,”Norovirus is one of the main pathogens causing nonbacterial gastroenteritis in infants and young children. Clinical symptoms in norovirus infection include nausea, vomiting, diarrhea, abdominal pain among which vomiting is obvious. Due to the lack of effective research models, the pathogenesis of Norovirus infection is still unclear. This article focuses on the progress in research of the pathogenic mechanism of Norovirus, and mainly discusses the cell phagocytosis and immune response.