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目的 :回顾性分析放疗 (R)联合替尼泊苷 +司莫司汀化疗 (C)治疗脑转移瘤的疗效和毒副反应。方法 :1993年 3月～ 1998年 12月间收治放疗加化疗 (R +C)病人 30例 ,与同期收治的单纯放疗 (R) 4 2例进行观察比较。结果 :12个月、 >12个月生存率及局部控制率R +C组分别为 2 6 .7% ,2 3 .3 %和 40 .0 % ,R组分别为 16 .2 % ,2 .4%和 19.0 %。 >12个月生存率及局部控制率两组间具有差异显著性 (P <0 .0 5 )。胃肠道反应、脱发等两组基本相似 ,白细胞下降R +C组为 90 .0 % ,其中Ⅲ度占 33.3 % ,R组为 73.8% ,无Ⅲ度及Ⅳ度。结论 :R +C组疗效优于R组 ,但骨髓抑制亦较明显。
Objective: To retrospectively analyze the curative effect and toxicity of radiotherapy (R) combined with teniposide and semustine chemotherapy (C) in the treatment of brain metastases. Methods: From March 1993 to December 1998, 30 patients were treated with radiotherapy plus chemotherapy (R + C) and 42 patients with radiotherapy alone (R) treated in the same period. Results: The 12-month,> 12-month survival rates and local control rates were 26.7%, 23.3% and 40.0% in R + C group and 16.2% in R group respectively. 4% and 19.0%. > 12-month survival rate and local control rate were significantly different between the two groups (P <0.05). Gastrointestinal reactions, hair loss and other two groups were similar, leukopenia R + C group was 90.0%, of which 33.3% Ⅲ, 73.8% of the R group, Ⅲ and Ⅳ degrees. Conclusion: The efficacy of R + C group is better than that of R group, but the bone marrow suppression is more obvious.