动脉粥样硬化是一慢性炎症反应,肥胖为其一独立危险因子。由于脂肪组织是体内大部分炎症反应因子的重要来源,这些炎症因子通过多种途径导致动脉内皮的损伤、细胞的迁移增殖和脂质的沉积。本文重点从分子机制对其进行阐述,以便为预防肥胖致动脉粥样硬化提供更多的新思路。 Atherosclerosis is a chronic inflammatory reaction and obesity is an independent risk factor. Since adipose tissue is an important source of most of the inflammatory response factors in the body, these inflammatory factors lead to damage of the arterial endothelium, migration and proliferation of cells and deposition of lipids through a variety of pathways. This article focuses on the molecular mechanism of its elaboration, in order to prevent obesity caused by atherosclerosis provide more new ideas.