卵巢功能衰退后冠心病 (ＣＨＤ)的发病率明显升高 ,经性激素替代治疗 (ＨＲＴ)后 ,可使绝经后妇女ＣＨＤ的发病率降低 5 0 % [1] 。起初认为 ,这种变化是脂代谢引起的 ,近年来发现雌激素 (Ｅ)还可引起心血管系统的其他效应 ,如Ｅ对动脉壁和心肌有直接作用[2 ] 。鉴于这一点 ,我 After ovarian failure, the incidence of coronary heart disease (CHD) is significantly increased. After the hormone replacement therapy (HRT), the incidence of CHD can be reduced by 50% in postmenopausal women [1]. At first thought, this change is caused by lipid metabolism, in recent years, estrogen (E) also found that the cardiovascular system can cause other effects, such as E on the arterial wall and myocardium have a direct role [2]. In view of this, I