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目的 对应用活性炭细小微粒吸附抗癌药进行局部治疗各种肿瘤的效果、应用方法和毒副作用进行观察。方法 晚期恶性肿瘤病人27例,其中消化道肿瘤26例,乳腺癌1例。将经气流粉碎制成的活性炭微粒吸附顺铂、卡铂或丝裂霉素,经内镜癌灶注射、胸或腹腔注射,进行局部用药治疗。结果 用活性炭吸附丝裂霉素治疗消化道肿瘤病人22例,临床症状均获缓解,瘤体缩小或消失者3例。生存6个月以上者16例,1年以上者3例。用顺铂和丝裂霉素治疗5例,其中乳腺癌1例,胃、肝转移4例,随访6～8个月,也均有好转。除腹腔注射有胃肠道症状及发热之外,无严重副作用。结论 用活性炭吸附抗癌药局部注射,可使癌肿周围药物浓度较高,提高治疗效果,且毒副作用较小,是一种有希望的治疗方法。
Objective To observe the effects, application methods and toxic and side effects of local application of anti-cancer drugs for the local treatment of various tumors with activated carbon fine particles. Methods Twenty-seven patients with advanced malignant tumor included 26 cases of digestive cancer and 1 case of breast cancer. The activated charcoal particles made by the air flow pulverization adsorbed cisplatin, carboplatin or mitomycin and were administered by endoscopic injection, chest or intraperitoneal injection for topical drug treatment. Results Twenty-two patients with digestive tract cancer were treated with activated carbon and mitomycin C. All the clinical symptoms were relieved. The tumors were reduced or disappeared in 3 patients. Sixteen patients survived for more than six months, and three patients had one or more years. Five patients were treated with cisplatin and mitomycin, including 1 case of breast cancer and 4 cases of gastric and hepatic metastases. All cases were followed up for 6 to 8 months. In addition to abdominal gastrointestinal symptoms and fever, there are no serious side effects. Conclusion Local injection of anticancer drugs with activated charcoal can make the concentration of drugs around the cancer higher, improve the therapeutic effect, and have fewer side effects, which is a promising treatment.