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目的探讨异舒吉(二硝酸异山梨酯)联合低分子肝素治疗不稳定型心绞痛(UAP)的疗效。方法60例UAP患者随机分为2组,治疗组30例,对照组30例。2组均给予常规治疗,治疗组加用异舒吉静脉滴注联合低分子肝素皮下注射;对照组加用硝酸甘油静脉滴注。2组连续观察7d。结果治疗组有效率96.7%,对照组有效率80%。治疗组凝血酶原时间(PT)及纤维蛋白原定量(FIB)与对照组比较差异有统计学意义(P<0.01),用药后部分出凝血指标与对照组比较有明显变化,但均在正常范围内。不良反应方面,治疗组明显优于对照组。结论异舒吉联合低分子肝素治疗不稳定型心绞痛临床疗效明显,安全,不良反应小。
Objective To investigate the efficacy of Isosorbide (Isosorbide dinitrate) combined with low molecular weight heparin in the treatment of unstable angina pectoris (UAP). Methods Sixty UAP patients were randomly divided into two groups: 30 cases in the treatment group and 30 cases in the control group. 2 groups were given conventional treatment, the treatment group plus Isocitrate intravenous infusion of low molecular weight heparin subcutaneous injection; control group plus nitroglycerin intravenous infusion. 2 consecutive observation group 7d. Results The effective rate of the treatment group was 96.7% and that of the control group was 80%. The treatment group, prothrombin time (PT) and fibrinogen (FIB) compared with the control group, the difference was statistically significant (P <0.01), after administration of some of the coagulation index compared with the control group were significantly changed, but were normal Range. Adverse reactions, the treatment group was significantly better than the control group. Conclusion Isoflurane combined with low molecular weight heparin in the treatment of unstable angina pectoris has obvious curative effect, safety and adverse reaction.