目的探究经鼻孔蝶窦入路神经内镜下垂体瘤切除术对老年垂体瘤患者预后的影响。方法选取2011年5月至2014年5月本院收治的老年垂体瘤患者104例为研究对象,将其随机分为观察组和对照组,入院后均予以常规处理,观察组患者在神经内镜下行垂体瘤切除术,对照组患者在显微镜下行垂体瘤切除术。随访1年,比较两组患者围术期情况、术后并发症发生情况及预后。结果观察组患者手术时间、术中出血量、术后住院时间均明显少于对照组(P<0.05)。两组患者并发症总发生率比较差异具有显著性(P<0.05)。术后6个月观察组患者临床表现改善率为79.2%,对照组为64.0%;术后1年观察组患者临床表现改善率为93.8%,对照组为72.0%;差异均具有显著性(P<0.05)。结论经鼻孔蝶窦入路神经内镜下垂体瘤切除术对老年垂体瘤患者疗效显著,且并发症少,预后良好,值得临床推广应用。 Objective To investigate the effect of transnasal sphenoid sinus endoscopic pituitary tumor resection on the prognosis of elderly patients with pituitary adenoma. Methods A total of 104 elderly patients with pituitary adenoma treated in our hospital from May 2011 to May 2014 were selected as study subjects and randomly divided into observation group and control group. All patients were treated routinely after admission. The patients in observation group underwent neuroendoscopy Down pituitary tumor resection, the control group underwent pituitary tumor resection under the microscope. The patients were followed up for 1 year. The perioperative status, postoperative complications and prognosis were compared between the two groups. Results The operation time, intraoperative blood loss and postoperative hospital stay in observation group were significantly less than those in control group (P <0.05). The total incidence of complications between the two groups was significantly different (P <0.05). The improvement rate of clinical manifestations in observation group was 79.2% at 6 months after operation, and 64.0% in control group. The improvement rate of clinical manifestation in observation group was 93.8% at 1 year after surgery and 72.0% in control group. The difference was significant (P <0.05). Conclusion Nose transsyn spinal approach neuroendoscopic pituitary tumor resection in elderly patients with pituitary tumor significant effect, and fewer complications, the prognosis is good, worthy of clinical application.