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目的 :观察山莨菪碱对豚鼠实验性鼻超敏反应的影响。方法 :将实验动物分为正常对照组 ,二异氰酸甲苯脂 (TDI)致敏组 ,利血平组和山茛菪碱组 ,以其鼻部症状记分及鼻粘膜细胞学的变化作为观察项目。结果 :利血平组鼻部症状较 TDI致敏组明显加重 ,鼻粘膜嗜酸性粒细胞明显增高 ,其差异有极显著性意义 (均 P <0 .0 1)。山莨菪碱组鼻部症状明显减轻 ,嗜酸性粒细胞数明显减少 ,与利血平组比较 ,差异有显著性意义 (均 P <0 .0 1)。结论 :以副交感神经兴奋为主的鼻超敏反应性疾病 ,经鼻给予山莨菪碱有一定治疗作用。
Objective: To observe the effect of anisodamine on experimental nasal hypersensitivity in guinea pigs. Methods: The experimental animals were divided into normal control group, TDI-sensitized group, reserpine group and anisodamine group. Their nasal symptom scores and changes of nasal mucosa cytology were observed project. Results: The nasal symptoms in reserpine group were significantly aggravated compared with TDI sensitized group, and nasal mucosal eosinophils were significantly increased (P <0.01). Anisodamine significantly reduced nasal symptoms and decreased eosinophils, which were significantly different from those of reserpine group (P <0.01). CONCLUSIONS: Nasal hypersensitivity diseases, which are mainly excitatory parasympathetic nerves, have some therapeutic effects via nasal administration of anisodamine.