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目的:分析胰腺癌的临床特征、治疗方式和生存状态,探讨胰腺癌预后因素。方法:回顾分析新疆医科大学第一附属医院2002-01-01-2011-12-31收治的353例维吾尔族和汉族胰腺癌患者的临床资料,应用Kaplan-Meier法计算生存率,并对可能影响患者预后的因素进行单因素分析(Log-rank检验),再用Cox比例风险模型对单因素分析有意义的因素进行多因素统计分析。结果:353例胰腺癌患者中位生存期为167d,0.5、1、2和5年生存率分别为47.1%、23.6%、11.4%和4.2%,其中维吾尔族和汉族患者的中位生存期分别为158和167d,0.5年生存率分别为46.7%和47.4%,1年生存率分别为24.8%和23.4%,2年生存率分别为12.8%和10.6%,差异无统计学意义,P>0.05。单因素分析显示,ECOG体力状况(ZPS)评分、临床分期、肿瘤部位及大小、有无手术及放化疗、治疗前血清癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原242(carbohydrate antigen 242,CA242)、糖类抗原199(carbohydrate antigen 199,CA199)水平与预后相关,P<0.001;多因素分析显示,ECOG体力状况(ZPS)评分、临床分期、肿瘤大小、有无手术及放化疗、治疗前血清CA242HE CA199水平可作为独立预后因素,P<0.05。结论:维吾尔族和汉族胰腺癌患者生存率无明显差异,且一般状况好、临床分期早、进行根治性手术及辅助治疗早、CA242及CA199水平低的患者预后较好。
Objective: To analyze the clinical features, treatment and survival status of pancreatic cancer and explore the prognostic factors of pancreatic cancer. METHODS: The clinical data of 353 Uygur and Han patients with pancreatic cancer admitted to the First Affiliated Hospital of Xinjiang Medical University from 2002-01-01 to 2011-12-31 were analyzed retrospectively. The Kaplan-Meier method was used to calculate the survival rate and possible influences. The prognostic factors of the patients were analyzed by the univariate analysis (Log-rank test), and multivariate statistical analysis was performed using the Cox proportional hazards model for factors that were significant for univariate analysis. Results: The median survival time of 353 patients with pancreatic cancer was 167 days. The 0.5, 1, 2 and 5 year survival rates were 47.1%, 23.6%, 11.4% and 4.2% respectively. The median survival time of Uygur and Han patients were For 158 and 167d, the 0.5-year survival rates were 46.7% and 47.4%, respectively. The one-year survival rates were 24.8% and 23.4%, and the 2-year survival rates were 12.8% and 10.6%, respectively, with no statistically significant difference. P>0.05 . Univariate analysis showed that the ECOG performance status (ZPS) score, clinical stage, tumor size and size, with or without surgery, radiotherapy and chemotherapy, pretreatment serum carcinoembryonic antigen (CEA), carbohydrate antigen 242, CA242) and carbohydrate antigen 199 (CA199) levels were associated with prognosis, P<0.001; multivariate analysis showed that ECOG physical status (ZPS) score, clinical stage, tumor size, with or without surgery, radiotherapy and chemotherapy, and treatment Pre-sera CA242HE CA199 level can be used as an independent prognostic factor, P<0.05. Conclusion: There is no significant difference in the survival rate between Uygur and Han patients with pancreatic cancer. The prognosis is better in patients with good general condition, early clinical stage, radical surgery and adjuvant therapy, and low levels of CA242 and CA199.