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目的:探讨螺旋藻对力竭运动大鼠胃溃疡的作用。方法:60只SD大鼠随机分为安静对照组、力竭运动组和实验组。安静对照组和力竭运动组普通饲料喂养,实验组采用添加螺旋藻的饲料喂养;力竭运动组和实验组每天进行游泳训练,共4周,最后1天进行力竭性无负重游泳运动后即刻,观察各组大鼠胃溃疡指数,胃液量、总酸度、胃蛋白酶活性和前列腺素E(PGE)含量以及胃组织丙二醛(MDA)、一氧化氮(NO)的含量。结果:力竭运动后大鼠发生应激性溃疡,力竭运动组胃液量和PGE含量较安静对照组降低,总酸度、胃蛋白酶活性无改变;胃组织MDA、NO含量增加。服用螺旋藻的实验组溃疡指数较力竭运动组下降;胃液量、总酸度、胃蛋白酶无明显改变,PGE含量较力竭运动组升高;胃组织MDA含量较力竭运动组降低,NO无明显改变。结论:螺旋藻通过减少力竭运动后脂质过氧化、增加PGE抗运动性胃溃疡。
Objective: To investigate the effect of spirulina on gastric ulcer in rats after exhaustive exercise. Methods: Sixty SD rats were randomly divided into quiet control group, exhaustive exercise group and experimental group. Quiescent control group and exhaustive exercise group were fed with normal diet. The experimental group was fed with spirulina diet. The exhausted exercise group and the experimental group were given daily swimming training for 4 weeks and the last day after exhaustive non-weight-bearing swimming exercise Immediately, gastric ulcer index, gastric juice volume, total acidity, pepsin activity, prostaglandin E (PGE) content, and content of malondialdehyde (MDA) and nitric oxide (NO) in gastric tissue were observed. Results: After exhaustive exercise, stress ulcer occurred in rats. The amount of gastric juice and PGE in exhaustive exercise group were lower than those in the quiet control group, while the total acidity and pepsin activity did not change. The content of MDA and NO in gastric tissue increased. The experimental group with Spirulina ulcer index decreased compared with the exhaustive exercise group; gastric juice volume, total acidity, pepsin had no significant change, PGE content than the exhaustive exercise group increased; gastric tissue MDA content than the exhaustive exercise group, NO Significant change. CONCLUSIONS: Spirulina increases PGE against exercise-induced gastric ulcer by reducing lipid peroxidation after exhaustive exercise.