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目的 研究口腔鳞癌中ｎ ｍ２３ － Ｈ１ 基因的ｍ Ｒ Ｎ Ａ 表达情况及其与口腔鳞癌颈淋巴结转移的关系。方法 采用斑点杂交的方法检测８ 例口腔鳞癌，２ 例正常口腔粘膜中ｎ ｍ２３ － Ｈ１ 基因的ｍ Ｒ Ｎ Ａ 表达情况。结果 ２例正常口腔粘膜中ｎｍ２３ － Ｈ１ 基因的ｍ Ｒ Ｎ Ａ 表达水平均较高；４ 例手术时无颈淋巴结转移的口腔鳞癌组织中３ 例ｎｍ２３ － Ｈ１ ｍ Ｒ Ｎ Ａ 呈相对高表达，１ 例表达水平较低；而伴有颈淋巴结转移的４ 例口腔鳞癌组织中ｎｍ２３ － Ｈ１ ｍ Ｒ Ｎ Ａ 均为相对低表达。结论 提示ｎｍ２３ － Ｈ１ 基因ｍ Ｒ Ｎ Ａ 的低水平表达可能与口腔鳞癌的颈淋巴结转移有关
Objective To study the m R N A expression of n m23 - H1 gene in oral squamous cell carcinoma and its relationship with cervical lymph node metastasis in oral squamous cell carcinoma. Methods Dot blot hybridization was used to detect the m R N A expression of n m23 - H1 gene in 8 cases of oral squamous cell carcinoma and 2 normal oral mucosa. Results The mR N A expression levels of nm23-H1 gene in 2 normal oral mucosa were high, and 3 cases of nm23-H1 m R N A were relatively highly expressed in 4 cases of oral squamous cell carcinoma without cervical lymph node metastasis. In one case, the expression level was low; however, the nm23-H1 m R-NA was relatively low in 4 cases of oral squamous cell carcinoma with cervical lymph node metastasis. Conclusions The low level expression of nm23-H1 gene m R N A may be related to cervical lymph node metastasis in oral squamous cell carcinoma