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[目的]分析延边地区朝鲜族与汉族女性感染人乳头瘤病毒(HPV)的基因型分布特点.[方法]采用HPV基因分型技术对4 208例在妇科门诊就诊的妇女进行HPV分型检测.[结果]4 208例妇女中HPV感染率为36.29%(1 527例),共有2 176人次感染.HPV16,52,58及53型是HPV感染的较常见亚型,构成比分别为18.47%(402例),12.87%(280例),12.59%(274例),8.96%(195例);单一感染率为70.33%(1 074例),多重亚型感染率为29.67%(453例);HPV感染高峰年龄段为50~59岁和>60岁,感染率分别为43.59%和52.60%;朝鲜族HPV感染阳性检出率为38.11%(596例),汉族为34.86%(922例),两者间差异有统计学意义(P<0.05).[结论]延边地区女性HPV高危型感染以16,52,58,53型较常见,感染高发年龄段为50~59岁和>60岁,且朝鲜族与汉族HPV感染阳性检出率间有明显差异.
[Objective] To analyze the genotypic distribution of human papillomavirus (HPV) in Korean and Han nationality in Yanbian area. [Methods] HPV genotyping was used to detect 4 208 women in gynecology clinic. [Results] The prevalence of HPV infection among 4 208 women was 36.29% (1 527), with a total of 2 176 infections.PV 16, 52, 58 and 53 were the most common HPV subtypes with the constituent ratios of 18.47% 402 cases), 12.87% (280 cases), 12.59% (274 cases) and 8.96% (195 cases). The single infection rate was 70.33% (1 074 cases) and the multiple subtype infection rate was 29.67% (453 cases) The prevalence of HPV infection was 50- 59 years old and> 60 years old, and the infection rates were 43.59% and 52.60% respectively. The positive rate of HPV infection in Korean people was 38.11% (596 cases) and Han nationality was 34.86% (922 cases) The difference between the two groups was statistically significant (P <0.05). [Conclusion] The female high risk HPV infection in Yanbian area is more common in the types of 16, 52, 58 and 53, and the high infection age group is 50 to 59 years old and> 60 years old, There was a significant difference between the positive rates of HPV infection in Korean and Han nationality.