卵巢上皮性肿瘤为常见的妇科肿瘤,其发生、发展是由癌基因的激活、抑癌基因的失活、凋亡调控机制的紊乱等多步骤参与的复杂过程,其中凋亡调控机制的紊乱是很重要且被密切关注的一个环节。肿瘤细胞的凋亡抑制和过度增殖加速了肿瘤的恶性进展。因此,文章选择了Bcl-2、Bax、Survivin、Smac、Fas这5个具有代表性、关键性的凋亡调控基因来描述它们在卵巢上皮性肿瘤中的表达情况及演变规律。 Epithelial ovarian cancer is a common gynecological tumor. The occurrence and development of ovarian epithelial tumor are complicated processes involved in many steps, such as activation of oncogenes, inactivation of tumor suppressor genes, and disturbance of the regulatory mechanisms of apoptosis. The disorder of apoptosis regulatory mechanism is A very important and closely watched part. Apoptosis and hyperproliferation of tumor cells accelerate the malignant progression of the tumor. Therefore, we selected five representative and critical apoptosis regulatory genes of Bcl-2, Bax, Survivin, Smac and Fas to describe their expression and evolution in ovarian epithelial tumors.